METHOD OF PROGRESSIVE HYPOBIOSIS MODELING FOR HEMATOTHERMAL ANIMALS Russian patent published in 1994 - IPC

FIELD: experimental medicine and physiology. SUBSTANCE: α-methyldopa doze value 0,8-1,0 g per 1 kg of animal mass or a-methylparathirozen doze value 100-200 mg per 1 kg of animal mass is injected endo-muscle or endo-peritoneum. When animal comes to poikilothermous state 1-2 hours after first injection second injection is made by serotonin doze equal to 5-10 mg per 1 kg of animal mass. Then animal is immobilized and cooling to achieve narcotized state and animal body temperature can be reduced gradually during 30-40 minutes to 20-22 C without thermogenic reaction (masculine tremor). Physiological exchanging processing level being reduced by 70-80% with respect to normal state hypobiosis state is prolonging down to temperature 17 C (with positive-negative deviations equal to 1 C). When preparation agents are combining by other way time regime schedule is remained. EFFECT: more short time for hypobiosis state attaining equal to 1,5-2,5 hours. 4 cl