METHOD OF SYNTHESIS OF 3β-HYDROXYPREGN-5-EN-20-ONE Russian patent published in 1995 - IPC

Abstract RU 2026865 C1

FIELD: organic chemistry. SUBSTANCE: product: 3b-hydroxypregn-5-en-20-one, yield is 94-98%, m. p. is 186-190 C, [α]2D

⁰ = 25.9 degree (in chloroform), empirical formula is C₂₁H₃₁O₂. Reagent 1: 3β-hydroxypregna-5,16-diene-20-one acetate. Reagent 2: gaseous hydrogen. Reaction conditions: in the medium of lower alcohol in the presence of palladium oxide on aluminium oxide. Product is used as gestagenous preparation and used for progesterone synthesis. EFFECT: improved method of synthesis. 1 tbl

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RU 2 026 865 C1

Authors

Sorokina N.P.

Grinenko G.S.

Davydova V.K.

Popok E.B.

Dates

1995-01-20—Published

1989-12-14—Filed