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(19)

RU

(11)

2 125 059

(13)

C1

(51)

IPC

(21) (22)

Application

95117100/04, 1994-01-12

(22)

Actual filing date

1994-01-12

(45)

Published

1999-01-20

(72)

Inventor

Bernard Frehnk BishopMajkl Stefen PehjsiDehvid Osten Pehrri

(73)

Holder

Pfajzer Ink.

DERIVATIVES OF AVERMECTIN, PHARMACEUTICAL AND VETERINARY COMPOSITION, METHOD OF SYNTHESIS OF COMPOUNDS Russian patent published in 1999 - IPC

Abstract RU 2125059 C1

FIELD: organic chemistry. SUBSTANCE: invention relates to derivatives of avermectin of the formula (I): where dotted line means optional carbon-carbon bond R1H or OH; R2 is C1-C-alkyl, C3-C8-cycloalkyl; R3 - H or OH; R4 - H or a group that can be hydrolyzed in vivo. Invention relates to also a method of synthesis of these compounds, intermediate compounds, pharmaceutical or veterinary composition containing an effective amount of compound of the formula (I) and acceptable filling agent or carrier. Proposed compositions exhibit an antiparasitic activity. EFFECT: improved method of synthesis, enhanced antiparasitic activity. 8 cl, 26 ex, 1 tbl

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RU 2 125 059 C1

Authors

Bernard Frehnk Bishop

Majkl Stefen Pehjsi

Dehvid Osten Pehrri

Dates

1999-01-20—Published

1994-01-12—Filed

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