METHOD OF SYNTHESIS OF N-(HETEROCYCLYLAMINOCARBONYL)-ARYL- -SULFONEAMIDE ALKALINE SALTS AS WATER-SOLUBLE GRANULES Russian patent published in 1999 - IPC

FIELD: organic chemistry. SUBSTANCE: invention describes a method of synthesis of N-(heterocyclylaminocarbonyl)-arylsulfoneamides alkaline salts of the formula (I) where R₁ - Cl, COOCH₃; R₂ is CH₄,OCH₃; R₃ is CH₃; X is N, CH; M is Na, K as water-soluble granules that is carried out by interaction of equimolar amounts of the corresponding N-(heterocyclylaminocarbonyl)- -arylsulfoneamide (IV) and alkaline metal hydroxide followed by obtained salt granulation. Method is characterized in that salt producing, its crystallization and granulation is carried out in the single unit in fluidized layer by continuous feeding the dispersed an aqueous solution of alkaline metal hydroxide at concentration 35%, not less, and preferably 40-44% on layer of solid particles consisting of compounds (IV) and (I) and with addition of surface-active substance moving at the rate 3-11 m/s. Process is carried out at 20-40 C and at moisture 14%, not above, and preferably at 8-12%. EFFECT: high quality of the end product. 4 ex