SOLID DELIVERY SYSTEMS FOR CONTROLLED RELEASE OF INCLUDED MOLECULES AND METHOD FOR THEIR PREPARATION Russian patent published in 2002 - IPC

Abstract RU 2177785 C2

FIELD: medicine, medicinal forms. SUBSTANCE: method deals with glass-like carriers and transported substance. Carrier is taken out of stabilizing polyole and hydrophobic carbohydrate derivative (HCD). Stabilizing polyole refers to disaccharide, trisaccharide, oligosaccharide and their corresponding saccharine spirits. HCD has got carbohydrate basic chain and, at least, one hydroxyl group substituted by hydrophobic fragment. Transported substance is a pharmaceutical agent or biological modifier. Shape of a solid dosed delivery system is chosen out of press cakes, tablets, disks, films, suppositories, needles, microneedles, particles, microparticles, spheres, microspheres, powders and implanted means. In preference, carrier represents trehalose and transported substance represents cyclosporin A. EFFECT: a glass-like delivery system provides stability of transported substance and its safety with no activity losses due to various delivery types and rates of transported substance. 39 cl, 20 dwg, 6 tbl, 10 ex

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RU 2 177 785 C2

Authors

Roser Brjus Dzhozef

Kolako Kamilo

Dzherrou Mokhammad Abdel' Zakhra

Blejr Dzhulian Aleksandr

Kampinga Dzhaap

Vardell Dzhejms Levis

Daffi Dzhon Alistejr

Dates

2002-01-10Published

1995-08-04Filed