FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to derivatives of dolastatin-15 of the general formula (I): A-B-D-E-F-(G)r-(K)s-L where A, B, D, E, F, G and K mean residues of α-amino acids; s and r each means independently 0 or 1; L means monovalent radical, for example, amino-group, N-substituted amino-group, β-hydroxylamino-group, hydrazido-group, alkoxy-group, thioalkoxy-group, aminooxy-group or oximato-group. Except for, invention involves method of cancer treatment in mammal, for example, in humans that includes administration to mammal the effective amount of compound of the formula (I). EFFECT: valuable medicinal properties of derivatives. 39 cl, 3 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| PEPTIDE DERIVATIVES OR THEIR SALTS, PHARMACEUTICAL COMPOSITION | 1993 |
|
RU2116312C1 |
| ANTITUMOR PEPTIDES | 1996 |
|
RU2182911C2 |
| CYCLOALKYL DERIVATIVES, METHOD OF PREPARATION THEREOF, AND INTERMEDIATES | 1997 |
|
RU2197458C2 |
| METHOD OF PREPARING 3-PYRROLINE-2-CABOXYLIC ACID DERIVATIVES | 1997 |
|
RU2199529C2 |
| METHOD OF PRODUCING PYRAZOLES | 2015 |
|
RU2712192C2 |
| METHOD AND INTERMEDIATES COMPOUNDS FOR SYNTHESIS OF SIMPLE HYDROXYLAMINE ETHERS AND THEIR SALTS | 1993 |
|
RU2119911C1 |
| NOVEL FLUORESCENT COMPOUNDS | 2012 |
|
RU2587082C2 |
| METHOD OF SYNTHESIS OF OXIME ESTERS BY INTERACTION OF OXAMINE WITH DIALKYLCARBONATES | 1995 |
|
RU2167149C2 |
| BIFUNCTION CYTOTOXIC AGENTS CONTAINING PHARMACOPHORE CTI | 2016 |
|
RU2682645C1 |
| FIVE-MEMBERED HETEROCYCLES AS INHIBITORS OF LEUKOCYTE ADHESION AND VLA-4 ANTAGONISTS | 1997 |
|
RU2229296C2 |
