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Application

2001109802/04, 2001-04-11

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Start date

2001-04-11

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Actual filing date

2001-04-11

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Published

2003-01-20

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Inventor

Dzhemilev U.M.Parfenova L.V.Khalilov L.M.Valjamova F.G.Ivanova S.V.Nikitina E.V.Khafizova L.O.Ibragimov A.G.Beletskaja I.P.

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Holder

Institut Neftekhimii I Kataliza An Rb I Unts Ran

METHOD OF SYNTHESIS OF OPTICALLY ACTIVE DIMERIC COMPLEXES OF (1S,2S,5S)-(6'-METHOXYQUINOLYL-4')-(5-VINYL-1-AZABICYCLO-[2,2,2]-OCT-2-YL)-(DIALKYL-ALUMINA)-OXYMETHANES Russian patent published in 2003 - IPC

Abstract RU 2196773 C2

FIELD: organic chemistry, chemical technology. SUBSTANCE: invention describes method of synthesis of optically active dimeric complexes of (1S,2S, 5S)-(6'-methoxyquinolyl-4')-(5-vinyl-1-azabicyclo-[2.2.2] -oct-2-yl)-(dialkylalumina)-oxy-methanes of the general formula (1) where R means C2H5, n-C3H7, i-C4H9 involving interaction of (1S,2S,5S)-(6'-methoxyquinolyl-4')-(5-vinyl-1-azabicyclo-[2.2.2]-oct-2-yl)-carbinol hydrochloride (quinine hydrochloride) with aluminium dialkylhydrides HAIR2 where R is determined above in the mole ratio = 10: (25-35) in argon atmosphere at the room temperature and under normal pressure in benzene medium for 0.5-1.5 h. The proposed method can be used in fine organic and metalloorganic synthesis, in part, in synthesis of pure enantiomers of compounds with high optical yields. EFFECT: improved method of synthesis. 1 tbl

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RU 2 196 773 C2

Authors

Dzhemilev U.M.

Parfenova L.V.

Khalilov L.M.

Valjamova F.G.

Ivanova S.V.

Nikitina E.V.

Khafizova L.O.

Ibragimov A.G.

Beletskaja I.P.

Dates

2003-01-20—Published

2001-04-11—Filed

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