FIELD: medicine, virology, pharmacy. SUBSTANCE: invention relates to agent for topical application with prolonged effect that represents an antiviral agent comprising human leukocyte interferon and a base made as a plate. The base comprises collagen being interferon activity in plate is 3 000 IU, not less. Invention provides the development of novel medicinal preparation for topical application comprising human leukocyte interferon as a plate and exhibiting biological availability and comfortable using. Invention can be used in stomatology, surgery, otorhinolaryngology and gynecology for treatment of patients with herpetic and other infections caused by viruses and microorganisms. EFFECT: improved and valuable medicinal properties of agent. 1 tbl
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