FIELD: organic chemistry, biochemistry, pharmacy. SUBSTANCE: invention relates to crystalline forms of 3-(2,4-dichlorobenzyl)-2-methyl-N-(pentylsulfonyl)-3H-benzimidazole-5-carboxamide that are distinguished by data of powder X-rays diffraction. Invention describes also pharmaceutical compositions eliciting hypoglycemic activity and inhibition of activity of PDE5 PDE5, (phosphodiesterase-5) based on these crystalline forms. Invention provides preparing new forms of 3-(2,4- dichlorobenzyl)-2-methyl-N-(pentylsulfonyl)-3H-benzimidazole-5-carboxamide that show stability of physicochemical and biological properties. EFFECT: improved preparing method, valuable properties. 10 cl, 6 dwg, 4 ex
Title |
Year |
Author |
Number |
P-TOLUENESULPHONATE FOR MEK KINASE INHIBITOR AND CRYSTALLINE FORM THEREOF, AND METHOD FOR PRODUCTION THEREOF |
2016 |
- U Guajli
- Gao Syaokhuej
- Byan Lin
- Tszya Tszyunlej
|
RU2704251C2 |
STABLE CRYSTALLINE FORM OF TYPIRACYL HYDROCHLORIDE AND METHOD FOR ITS CRYSTALLIZATION |
2014 |
- Kadzuno Khideki
- Mutsumi Tomonobu
|
RU2640417C2 |
STABLE CRYSTALLINE FORM OF TIPIRACIL HYDROCHLORIDE AND METHOD FOR ITS CRYSTALLIZATION |
2014 |
- Kadzuno Khideki
- Mutsumi Tomonobu
|
RU2674441C1 |
SALT OF MONOCYCLIC DERIVATIVE OF PYRIDINE AND CRYSTAL THEREOF |
2015 |
- Ozaki Shunsuke
- Yoshida Kenshi
|
RU2658821C1 |
CRYSTALLINE FORM OF INHIBITOR BISULPHATE JAK AND METHOD FOR PRODUCTION THEREOF |
2015 |
- Sun Pyaoyan
- U Guajli
- Gao Syaokhuej
- Chen Yuntszyan
- Shen Lintszya
|
RU2704795C2 |
SALT OF PYRROLIDIN-3-YL-ACETIC ACID DERIVATIVE AND ITS CRYSTALS |
2014 |
|
RU2640047C2 |
2-[4-(METHYLAMINOMETHYL)PHENYL]-5-FLUORO-BENZOFURAN-7-CARBOXAMIDE HYDROCHLORIDE POLYMORPHOUS, METHOD FOR ITS PRODUCTION AND APPLICATION |
2018 |
- Yang, Chunhao
- Miao, Zehong
- Tan, Cun
- Huan, Xiajuan
- Ding, Jian
- Chen, Yi
|
RU2783418C1 |
CRYSTAL (6S,9AS)-N-BENZYL-8-({6-[3-(4-ETHYLPIPERAZIN-1-YL)AZETIDIN-1-YL]PYRIDIN-2-YL}METHYL)-6-(2-FLUORINE-4-HYDROXYBENZYL)-4,7-DIOXO-2-(PROP-2-EN-1-YL)HEXAHYDRO-2H-PYRAZINO[2,1-C][1,2,4]TRIAZINE-1(6H)-CARBOXAMIDE |
2016 |
|
RU2723551C2 |
CRYSTAL FORM OF PARP-1 INHIBITOR AND ITS PRODUCTION METHOD |
2018 |
- Li, Wenhai
- Zhang, Quanliang
- Qiu, Zhenjun
- Li, Zhengming
|
RU2792620C2 |
NEW CRYSTALS OF URACIL COMPOUND |
2016 |
|
RU2686722C1 |