METHODS FOR PREPARING ERGOT ALKALOIDS PHARMACEUTICAL COMPOSITIONS WITH PROLONGED EFFECT CHARACTERIZING WITH IMPROVED BIOAVAILABILITY AND COMPOSITIONS COMPRISING INDICATED ALKALOIDS Russian patent published in 2005 - IPC

FIELD: organic chemistry, natural compounds, pharmacy.

SUBSTANCE: method involves mixing ergot derivative or its mixture with pharmaceutically acceptable hydrophilic swelling substance or its mixture and with one or some pharmaceutically acceptable vehicles. Derivative of ergot has the following formula: wherein R₁ means hydrogen or halogen atom; R₂ means hydrogen atom or (C₁-C₄)-alkyl; R₃ represents isopropyl, sec.-butyl, isobutyl or benzyl; R₄ represents methyl, ethyl or isopropyl; R₅ means hydrogen atom; R₆ means hydrogen atom or methoxy-group, or R₅ and R₆ in common correspond to the additional bond. The ratio of ergot derivative to swelling agent = (1-0.5):(1-10). Pharmaceutical composition containing the substance prepared by above indicated method comprises from 5 to 80 mg of ergot derivative in its ratio to swelling agent from 1:0.5 to 1:10. Invention provides realization the indicated designation.

EFFECT: improved methods for preparing, valuable properties of compositions.

6 cl, 6 tbl, 1 dwg, 8 ex