FIELD: organic chemistry, chemical technology.
SUBSTANCE: invention relates to the improved method for preparing 1-(3-sulfamoyl-4-chlorobenzoyl)-amino-2-methylindoline. Method involves acylation reaction of 1-amino-2-methylindoline hydrochloride with 4-chloro-3-sulfamoylbenzoyl chloride in dioxane medium. Firstly, 1 mole of triethylamine is added and then 4-chloro-3-sulfamoylbenzoyl chloride in dioxane is added in parallel, and then remaining 1.11 mole of triethylamine in dioxane is added and pH value is maintained in the range 7.5-8. Method provides enhancing yield of the end product up to 88% as compared with 80.5% and to replace using tetrahydrofurane for dioxane.
EFFECT: improved preparing method, enhanced yield of product.
2 ex
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