METHOD FOR PREDICTING TOXIC ENCEPHALOPATHY CASES CAUSED BY CHEMICAL COMPOUNDS COMPLEX Russian patent published in 2007 - IPC A61B5/295 A61B5/476 A61B5/16 

FIELD: medicine.

SUBSTANCE: method involves collecting anamnesis data, carrying out rheoencephalogram examination (REG), electroencephalogram examination (EEG) and standardized multifactorial person analysis test (SMPAT). Diagnostic coefficients F₁ and F₂ are calculated from formulas: F₁ = 58.29+0.15xa₁+266.1xa₂+0.24xa₃+ 7.67xa₄+4.87xa₅ + 10.8xa₆-З.54xa₇ +0.15xa₈ + 0.5xa₉, F₂=84.08+0,22xa₁ + 152.4xa₂+0.14xa₃ + 11.5xa₄+8.4xa₅ + 12.3xa₆-3.79xa₇+0.37xa₈+0.64xa₉, where F₁ and F₂ are diagnostic coefficients; digital parameters are constants and discrimination factors; а₁ is the venous discharge parameter on REG in frontomastoidal lead, in %; a₂ is the cerebral blood circulation intensity parameter on REG in occipitomastoidal lead in Ohms; a₃ is the cerebral blood vessel tone intensity parameter on REG in occipitomastoidal lead, in %; a₄ is the cerebral blood vessels response type in carrying out antiorthostatic test when 0, it is normotonic, 1 - hyperconstrictor one, 2 - perverted one; a₅ - is the cerebral blood vessels response type in carrying out hyperventilation test, when 0, it is hyperconstrictor type, 1 - hyperconstrictor type, 2 - perverted one; a₆ is the degree of general cerebral changes shown on EEG, when 0, the changes are mild, when 1 - moderate, 2 - expressed; a₇ points on median structures dysfunction shown on EEG, when 0, none are available, when 1, upper trunkal one is available, 2 - lower trunkal one is available; a₈ is the T-points value according to SMPAT scale 1; а₉ - is the T-points value according to SMPAT scale 3. Forecasting conclusion is drawn with function of greater value taken into consideration. F₁>F₂ gives base to draw conclusion of no influence exerted by chemical substances upon organism. The conclusion of intoxication consequences caused by chemical substances complex is drawn, if F₂≥F₁. Prognosis index PI value is calculated from formula: PI = 1/(1+e-(F₂ - F₁)), where е is the natural logarithm base equal to 2.72... . 0.5≤PI≤0.84 is considered as mean value, and 0.85≤PI≤1 as superior value.

EFFECT: high accuracy of prognosis.

1 tbl