METHOD FOR PREPARING C -BUTYRATE SODIUM Russian patent published in 2007 - IPC A61K51/00 

FIELD: pharmacy, labeled compounds.

SUBSTANCE: invention relates to a method for synthesis of ¹¹C-butyrate sodium that represents drugs, namely, radionuclides-labeled compounds. Method involves nuclear reaction of ¹⁴N(p,α)¹¹C by irradiation of nitrogen atom of natural isotope composition by protons with energy 13-15 Mev in cyclotron. Then method involves interaction of prepared carbon-11 with oxygen to form carbon-11 dioxide, reaction of carbon-11 dioxide with propylmagnesium bromide in anhydrous diethyl ether, isolation of ¹¹C-butyric acid, addition of stoichiometric amount of 0.2 M hydrochloric acid to reaction mixture and isolation of the end substance by solid-phase extraction on a microcolumn filled with reversed-phase resin and the following elution of the end substance with sodium hydrocarbonate. Method provides high and stable yield of the end substance (60 ± 2%), reducing synthesis time to 12 min (as compared with 20 min in prototype), Also, method provides creature of automatized modulus for synthesis the preparation and significant decreasing radiation loading on personnel carrying out synthesis. Invention can be used for synthesis of radiopharmaceutical preparations used in carrying out positron emission tomography.

EFFECT: improved method of synthesis.

2 cl, 1 ex