FIELD: organic chemistry, medicine, oncology, pharmacy.
SUBSTANCE: invention relates to using a combination that comprises the following components: (a) N-{5-[4-(4-methylpiperazinomethyl)benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidineamine and (b) chemotherapeutic agent chosen from zolendronic acid or letrozole wherein active components present in each case in free form or in form of pharmaceutically acceptable salt or their any hydrate. The composition is used for simultaneous, separate or successive using in aims for inhibition of progression or treatment of proliferative disease. Also, invention comprises a package containing above said components. Proposed invention group provides the synergetic therapeutic effect in treatment of diseases said above.
EFFECT: valuable medicinal properties and enhanced effectiveness of composition.
5 cl, 4 ex
