METHOD OF DIFFERENTIAL DIAGNOSIS OF NONSPECIFIC INFLAMMATORY AND MALIGNANT TUMOUR PROCESSES OF MUSCULOSCELETAL SYSTEM Russian patent published in 2008 - IPC A61B6/02 A61K51/04 

FIELD: medicine, radionuclide diagnostics.

SUBSTANCE: ¹⁹⁹Т1 chloride intravenous injection is followed by early planar scintigraphy in 20 min, visual determination of increased marker accumulation area, quantitative estimation of early accumulation in lesion (ER), additionally, delayed imaging is taken in 180 min following ¹⁹⁹Т1 chloride injection, at that, area of increased marker accumulation is determined repeatedly, accumulation intensity is determined quantitatively (DR), retention index (RI) is calculated as DR/ER and nonspecific inflammatory process is diagnosed if at least 2 of 3 following signs are found: RI<-0.047ER+0.979 in early and delayed imaging, borders of early marker hyperfixation area in early imaging are more distinct than in delayed phase of test, homogeneity of hyperfixation area in delayed imaging, while malignant tumour process is diagnosed if at least 2 of 3 following signs are found: RI>-0.047ER+0.979 in early and delayed imaging, less distinct borders of marker hyperfixation area in early imaging as compared to delayed imaging or without significant changes depending on imaging phase, heterogeneity of hyperfixation area in delayed imaging.

EFFECT: precision and informative value of differential diagnosis of nonspecific inflammatory and malignant processes of musculoskeletal system is increased as a result of enhanced qualitative and quantitative evaluation of scintigraphy image.

4 dwg, 1 tbl, 2 ex