Show metadata Hide metadata

(19)

(11)

2 335 506

(13)

(51)

IPC

C07K14/60(2006-01-01)

A61K38/25(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2006106701/04, 2004-07-26

(24)

Start date

2004-07-26

(22)

Actual filing date

2004-07-26

(45)

Published

2008-10-10

(72)

Inventor

Shelli Ehndrju V.Varga JozhefZarandi MartaTsaj Zhehn' Chzhi

(73)

Holder

Dze Administrejtors Of Dze T'Julejn Ehd'Jukejshnl FandDze Junajted Stehjts Of Amerika Reprezentid Baj Dze Dipartment Of Veterans Affehrs

PEPTIDE ANALOGUES GH-RH WITH OPPOSING ACTION, WAY OF DEPRESSION OF GH LEVEL, WAY OF DEPRESSION OF IGF-INIGF-II LEVEL, APPLICATION FOR INHIBITION OF GROWTH OF CANCER CELLS, PHARMACOLOGICALLY ACCEPTABLE COMPOSITION (VARIANTS) Russian patent published in 2008 - IPC C07K14/60 A61K38/25 A61P35/00

Abstract RU 2335506 C2

FIELD: medicine; pharmacology.

SUBSTANCE: new types of synthetic opposing analogues hGH-RH(1-29)NH₂ are offered. The given analogues inhibit interaction of endogenous hGH-RH with hypophyseal GH-RH receptors and thus interfere with release of a growth hormone. The analogues also suppress a proliferation in cancer tissues of the person by immediate influence on cancer cells. Increased inhibitory efficiency of the new analogues, in comparison with earlier described, is a consequence of replacement of different amino acids.

EFFECT: invention provides increase of efficiency of a composition and a method of treatment.

21 cl, 15 tbl, 12 ex

Similar patents RU2335506C2

Title	Year	Author	Number
ANTAGONISTIC ANALOGUES OF GROWTH HORMONE RELEASING-HORMONE (GH-RH) INHIBITING INSULIN-LIKE GROWTH FACTORS (IGF-I AND -II)	1999	Shehlli Ehndrju V. Varga Dzhozef Zarandi Marta	RU2235099C2
METHOD OF PRODUCING PEPTIDES	0	Zhan Eduard Frederik River Vili Vasker Vejl Iokhim Shpiss	SU1477248A3
CYCLIC PEPTIDES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, A METHOD OF THEIR SYNTHESIS	1992	Devid Robert Bolin[Us] Margaret O"Donnell[Us]	RU2095368C1
METHOD OF PRODUCING PEPTIDES	0	Dzhin Eduard Frederik River Vili Volker Vejl-Mladshij Katrin Laura River	SU1598881A3
PEPTIDE DERIVATIVES - ANALOGS OF GRF OR THEIR NONTOXIC SALTS	1990	Tereza M.Kubiak[Pl] Alan R.Fredman[Us]	RU2096416C1
METHOD FOR PREPARATION OF POLYPEPTIDE WITH PROPERTIES OF FACTOR RELEASE OF GROWTH HORMONE	0	Emil Tomas Kajzer Gonal Veliselebi	SU1651787A3
METHOD OF PRODUCING PEPTIDES	0	Vili Uolker Vejl Zhan Eduard Frederik Rive	SU1530097A3
DERIVATIVES OF NONAPEPTIDES OR THEIR SALTS WITH PHARMACEUTICALLY ACCEPTABLE ACIDS, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION	1991	Ehndrju V.Shelli Ren Zi Kaj	RU2115659C1
METHOD OF PRODUCING PEPTIDES	0	Zhan Edvard Frederik Rive Vili Uolker Vejl	SU1435157A3
METHOD OF OBTAINING PEPTIDES	0	Zhan Eduard Frederik River Vili Valker Vejl Iokhim Shpiss	SU1575944A3

RU 2 335 506 C2

Authors

Shelli Ehndrju V.

Varga Jozhef

Zarandi Marta

Tsaj Zhehn' Chzhi

Dates

2008-10-10—Published

2004-07-26—Filed