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(19)

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2 335 506

(13)

(51)

IPC

C07K14/60(2006-01-01)

A61K38/25(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2006106701/04, 2004-07-26

(24)

Start date

2004-07-26

(22)

Actual filing date

2004-07-26

(45)

Published

2008-10-10

(72)

Inventor

Shelli Ehndrju V.Varga JozhefZarandi MartaTsaj Zhehn' Chzhi

(73)

Holder

Dze Administrejtors Of Dze T'Julejn Ehd'Jukejshnl FandDze Junajted Stehjts Of Amerika Reprezentid Baj Dze Dipartment Of Veterans Affehrs

PEPTIDE ANALOGUES GH-RH WITH OPPOSING ACTION, WAY OF DEPRESSION OF GH LEVEL, WAY OF DEPRESSION OF IGF-INIGF-II LEVEL, APPLICATION FOR INHIBITION OF GROWTH OF CANCER CELLS, PHARMACOLOGICALLY ACCEPTABLE COMPOSITION (VARIANTS) Russian patent published in 2008 - IPC C07K14/60 A61K38/25 A61P35/00

Abstract RU 2335506 C2

FIELD: medicine; pharmacology.

SUBSTANCE: new types of synthetic opposing analogues hGH-RH(1-29)NH₂ are offered. The given analogues inhibit interaction of endogenous hGH-RH with hypophyseal GH-RH receptors and thus interfere with release of a growth hormone. The analogues also suppress a proliferation in cancer tissues of the person by immediate influence on cancer cells. Increased inhibitory efficiency of the new analogues, in comparison with earlier described, is a consequence of replacement of different amino acids.

EFFECT: invention provides increase of efficiency of a composition and a method of treatment.

21 cl, 15 tbl, 12 ex

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RU 2 335 506 C2

Authors

Shelli Ehndrju V.

Varga Jozhef

Zarandi Marta

Tsaj Zhehn' Chzhi

Dates

2008-10-10—Published

2004-07-26—Filed