BENZOTHIAZOLE DERIVATIVES AND THEIR APPLICATION IN TREATMENT OF DISEASES RELATED TO ADENOSINE A RECEPTORS Russian patent published in 2009 - IPC C07D417/04 C07D277/82 A61K31/428 A61P25/00 A61K31/5375 

FIELD: chemistry.

SUBSTANCE: invention concerns benzothiazole derivatives of general formula (I) and their pharmaceutically acceptable salts as adenosine receptor ligands and based medicinal product. Compounds can be applied in treatment and prevention of diseases mediated by A_2A adenosine receptors, such as Alzheimer's disease, some depressive states, toxicomania, Parkinson's disease. In the general formula (I) , R¹ is C₅-C₆-cycloalkyl substituted by CF₃ group, lower alkyl, -(CH₂)_nOH or -(CH₂)_n-O- lower alkyl, or is 1-bicyclo[2,2,1]hept-2-yl, 1-(7-oxa-bicyclo[2,2,1]hept-2-yl, 1-(5-exo-hydroxybicyclo[2,2,1]hept-2-exo-yl, 1-(5-exo-hydroxybicyclo[2,2,1]hepto-2-endo-yl, or is 1-adamantane-1-yl; R² is lower alkyl; or R¹ and R² together with N atom form 8-oxa-3-aza-bicyclo[3,2,1]octane group, n is 0 or 1.

EFFECT: improved efficiency of treatment.

9 cl, 2 dwg, 15 ex