BENZYLTRIAZOLONE DERIVATIVES AS NON-NUCLEOSIDE TRANSCRIPTASE INHIBITORS Russian patent published in 2010 - IPC C07D249/12 A61K31/4196 A61P31/18 

Abstract RU 2394028 C2

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula I and their pharmaceutically acceptable salts. In formula I R1 is a halide, (C1-C6)alkyl or (C1-C6)alkoxy group; R2 is hydrogen; R3 is phenyl, substituted with one or two substitutes independently selected from a group comprising halide(C1-C6)alkyl, halide and a cyano group; R4 is CH2OH, CH2OC(=O)(CH2)2C(=O)OH or CH2OC(=O)(C1-C6)alkyl; R5 is (C1-C6)alkyl. The invention also relates to use of the compounds to make a medicinal agent, to a pharmaceutical composition containing a therapeutically effective amount of the compound and to a method of obtaining formula I compounds.

EFFECT: obtaining compounds with HIV reverse transcriptase inhibiting properties.

9 cl, 2 tbl,11 ex

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RU 2 394 028 C2

Authors

Dann Dzhejms Patrik

Ehluorti Todd Richard

Stefanidis Dimitrios

Suini Zakari Kevin

Dates

2010-07-10Published

2005-07-20Filed