FIELD: chemistry.
SUBSTANCE: invention relates to chemical and pharmaceutical industry and specifically to an agent which is ethyl ether (±)-11,15-dideoxy-16-methyl-16-hydroxyprostaglandin E1 of formula 
(I), which exhibits uterotonic activity. This compound relates to the family of 11-deoxyprostaglandines and has a chemical structure similar to misoprostol.
EFFECT: agent, which is more chemically stable and is twice less toxic, surpasses misoprostol on uterotonic activity which, along with synthetic availability and absence of side effects, makes it exceptionally promising in practical use for replacing misoprostol in gynaecological binary preparations.
2 tbl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| AGENT REPRESENTING ETHYL ETHER (±)-11,15-DIDEOXY-16-METHYL-16-HYDROXYPROSTAGLANDIN E WITH OPTIMAL ABORTIVE ACTIVITY, COMBINED WITH MIFEPRISTONE | 2015 |
|
RU2612005C2 |
| METHOD FOR SYNTHESIS OF COMPOUND, SHOWING UTEROTONIC ACTION | 0 |
|
SU1768592A1 |
| METHOD OF PRODUCING (1E)-1-TRI-N-BUTYLSTANNYL-4-METHYL-4-TRIMETHYLSILOXYOCT-1-ENE | 2014 |
|
RU2560555C1 |
| COMPLEX OF CRYCYRRHIZINIC ACID WITH 9-OXO-11@@@, 15@@@-DIHYDROXY-13E-PROSTENIC ACID OR N-METHANE-SULPHONAMIDE OF 16-PHENOXY-17,18,19,20-TETRANOPROSTAGLADIN@@@, SHOWING UTEROTONIC ACTIVITY | 0 |
|
SU1566697A1 |
| METHOD OF UTERINE CERVIX PREPARATION FOR CHILDBIRTH WITH USE OF COMBINATION OF MIFEPRISTONE AND OSMOTIC DILATORS | 2018 |
|
RU2682574C1 |
| METHOD FOR PREVENTING UTERINE SUBINVOLUTION IN PUERPERAL PERIOD | 2002 |
|
RU2223102C1 |
| METHOD AND COMPOSITION FOR TREATING MUCOSAL INJURES | 2006 |
|
RU2445961C2 |
| PROSTAGLANDIN-CONTAINING PREPARATION FOR VETERINARY PURPOSE | 1997 |
|
RU2123336C1 |
| PROCESS FOR PREPARING DERIVATIVES OF 16-AMINO-18,19,20-TRINOR-PROSTAGLANDINE OR THEIR ACID ADDITION SALTS | 0 |
|
SU1093244A3 |
| METHYL ETHER (± ) 7-[2β-[1-AMINO-3-OXO-4-ACETOXI-(1E)-BUTENYL]-5-OXOCYCLOPENTYL-1a]HETANOIC ACID POSSESSING ANTIULCEROUS ACTIVITY | 1983 |
|
SU1221871A1 |
