6,7-UNSATURATED 7-CARBAMOYL SUBSTITUTED MORPHINANDERIVATIVE Russian patent published in 2010 - IPC C07D489/08 A61K31/485 A61P1/08 A61P1/10 A61P43/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to novel compound of general formula (I): , where R¹ and R², each independently, represent hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted cycloalkyl, optionally substituted aryl, etc., R³ represents hydrogen, hydroxy, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkinyl, optionally substituted lower alkoxy, etc, R⁴ represents hydrogen or lower alkyl, R⁵ represents hydrogen, lower alkyl, cycloalkyl-lower alkyl or lower alkenyl, or its pharmaceutically acceptable salt or solvate.

EFFECT: obtaining pharmaceutical composition for treatment and/or prevention of nausea, vomiting and/or constipation.

13 cl, 68 tbl, 4 ex