FIELD: medicine.
SUBSTANCE: in accordance with the described invention claimed are antiangiogenic (AA) compounds of targeted delivery, which include conjugates AA of targeted delivery agent with a linker, which are bound with antigen-binding site of antibody. Claimed are various applications of compounds, including methods of treating disorders associated with abnormal angiogenesis. Invention makes it possible to obtain compounds for targeted impact on Ang2 and demonstrates advantageous properties in comparison with existing Ang2-targeted agents.
EFFECT: in some aspects of invention useful agents and compounds in accordance with invention ensure attractive balance between period of half-life and IC50 values.
26 cl, 41 dwg, 10 tbl, 29 ex
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