METHOD FOR HYPOESTROGEN-INDUCED ENDOTHELIAL DYSFUNCTION CORRECTION WITH LOZARTAN IN COMPLEX WITH MIXED SOLUTIONS OF HOMOEOPATHIC DILUTIONS OF POLYCLONAL RABBIT C12, C30, C200 ANTIBODIES TO HUMAN ENDOTHELIAL NITROGEN OXIDE SYNTHASE Russian patent published in 2011 - IPC G09B23/28 A61K31/4184 A61K39/395 A61P9/02 

Abstract RU 2437162 C1

FIELD: medicine.

SUBSTANCE: hypoestrogen-induced endothelial dysfunction correction in white female Wistar rats, hypoestrogen-induced endothelial dysfunction is simulated by bilateral ovariectomy. The dysfunction correction is ensured by daily intragastric introduction of lozartan 6 mg/kg and daily introduction of mixed solutions of homoeopathic dilutions of polyclonal rabbit C12, C30, C200 antibodies to human endothelial nitrogen oxide synthase once a day added to drinking bowls.

EFFECT: method provides effective correction with reducing an endothelial dysfunction coefficient in females to the level observed in intact animals ensured by the effect on various developmental mechanisms of this dysfunction in hypoestrogenic conditions.

1 ex, 2 tbl

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RU 2 437 162 C1

Authors

Pokrovskij Mikhail Vladimirovich

Pokrovskaja Tat'Jana Grigor'Evna

Belous Aleksandr Sergeevich

Artjushkova Elena Borisovna

Belous Viktor Sergeevich

Gudyrev Oleg Sergeevich

Korokin Mikhail Viktorovich

Chernomortseva Elena Stanislavovna

Stabrovskaja Nadezhda Vladimirovna

Gureev Vladimir Vladimirovich

Kljavs Jurij Petrovich

Terekhova Elena Gennad'Evna

Kolesnik Inga Mikhajlovna

Jakushev Vladimir Ivanovich

Dolzhenkova Tat'Jana Vladimirovna

Korokina Lilija Viktorovna

Babko Anna Vladimirovna

Dates

2011-12-20Published

2010-04-26Filed