FIELD: medicine, pharmacy.
SUBSTANCE: invention refers to the field of medicine and pharmacy and refers to the method of production of tableted pharmaceutical form of clozapine (8-Chlorine-11 -(4-methylpiperasine-1-yl)-5H-dibenso [b, e][1, 4] diazepine). The essence of method is pre-produced dry mixture of lactose, potato starch and clozapine is hydrated by 10% water solution of Collidon 25, wet granulation is performed, and then drying is performed at temperature 45-50°C. Resulting granules are subject to dry granulation until the productions of granules with average diameter 1.0-1.5 mm, powdered with aerosil and stearic acid and/or its salt. The resulting mixture is pelletized and the tablets are produced with the following mixture ratio,%:
EFFECT: production of clozapine pharmaceutical composition in form of tablets.
2 cl, 5 ex
| Title | Year | Author | Number |
|---|---|---|---|
| PHARMACEUTICAL COMPOSITION OF PROLONGED ACTION BASED ON CLOZAPINE OF PERORAL INTRODUCTION | 2009 |
|
RU2414903C1 |
| PHARMACEUTICAL COMPOSITION FOR CORRECTION OF PSYCHOSOMATIC MANIFESTATIONS | 2009 |
|
RU2384336C1 |
| PHARMACEUTICAL COMPOSITION IN FORM OF HARD PERORAL DRUG FOR TREATMENT OF GASTROINTESTINAL TRACT DISEASES | 2009 |
|
RU2418576C2 |
| PHARMACEUTICAL COMPOSITION OF PROLONGED ACTION FOR CORRECTION OF PSYCHOSOMATIC MANIFESTATIONS | 2009 |
|
RU2424807C2 |
| PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING MENTAL, BEHAVIOUR AND COGNITIVE DISORDERS | 2012 |
|
RU2488388C1 |
| DRUG PREPARATION IN FORM OF ORALLY DISPERSIBLE TABLET AND METHOD FOR MAKING DRUG PREPARATION | 2012 |
|
RU2503447C1 |
| NEW THERAPEUTIC COMPOSITION FOR TREATING PAIN SYNDROME ACCOMPANYING SMOOTH MUSCLE SPASM | 2012 |
|
RU2497505C1 |
| DERIVATIVES OF 7-FLUORO-8-CHLORO-5H-DIBENZO [B, E] [1, 4] DIAZEPINE AND THEIR APPLICATION | 2014 |
|
RU2610169C2 |
| ORAL GINDARINE MEDICINE AND PRODUCTION METHOD | 2007 |
|
RU2360675C1 |
| RETARD TABLETS OF TRIMEBUTINE | 2013 |
|
RU2536254C1 |
