METHOD FOR PREPARING LITHIUM SALT OF COMENIC ACID AND USING IT AS ANTIOXIDANT, STRESS- AND NEUROPROTECTIVE AGENT Russian patent published in 2013 - IPC C07D309/40 A61K31/351 A61P25/00 

Abstract RU 2477722 C1

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to experimental medicine and pharmacology, namely a method for preparing lithium salt of comenic acid (lithium comenate) by mixing a comenic acid solution heated up to temperature max. 80±2°C, with lithium carbonate or hydroxide solution in the stoichiometrically-defined amounts, and colouring the solution in yellow and reducing pH of the solution to 4.6 or 10.0 respectively, and recovering luthium salt of comenic acid from the solution by water distillation under vacuum. For this purpose, lithium salt of comenic acid is suggested to be used in the amount of 2 mg per 1 kg of body weight once daily for 3 days.

EFFECT: invention refers to the agents for preventing and treating neurodegenerative diseases caused by an brain oxidative damage.

2 cl, 2 dwg, 5 tbl

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RU 2 477 722 C1

Authors

Shurygin Aleksej Jakovlevich

Zlishcheva Ehnna Ivanovna

Kravtsov Aleksandr Anatol'Evich

Androsova Tat'Jana Vasil'Evna

Skorokhod Natal'Ja Sergeevna

Abramova Natal'Ja Olegovna

Nemchinova Elena Aleksandrovna

Poleshchuk Larisa Afanas'Evna

Dates

2013-03-20Published

2011-07-27Filed