PHARMACEUTICAL COMPOSITIONS OF ENTACAPONE, LEVODOPA AND CARBIDOPA WITH IMPROVED BIOAVAILABILITY Russian patent published in 2013 - IPC A61K31/275 A61K31/198 A61K31/195 A61K9/14 A61K9/16 A61K9/26 A61K47/26

Abstract RU 2485947 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to medicine, namely to an oral pharmaceutical composition in the form of single doses, containing a combination of entacapone, levodopa and carbidopa, or salts thereof with one or more sugar alcohols; wherein entacapone is micronised together with one or more sugar alcohols, and a mixture of micronised entacapone and sugar alcohol prepared thereby has an average particle size less than 30 mcm.

EFFECT: invention enables higher dissolution rate in an aqueous media, absorption and bioavailability.

10 cl, 4 tbl, 1 ex

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RU 2 485 947 C2

Authors

Talvar Munish

Kapur Ritesh

Mashalkar Manodzh

Dzhain Girish Kumar

Dates

2013-06-27—Published

2009-02-06—Filed