PHARMACEUTICAL COMPOSITION EXHIBITING IMPROVED FLOWABILITY, DRUG PREPARATION, METHOD FOR PREPARING AND USING Russian patent published in 2013 - IPC A61K31/137 A61K47/32 A61K47/34 A61K47/26 A61K9/20 A61K9/48 A61J3/07 A61J3/10 A61P37/06 A61P31/18 A61P25/28 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutics, particularly to solid pharmaceutical compositions for the immune system suppression and multiple sclerosis treatment. The pharmaceutical composition exhibiting improved flowability contains a S1P receptor modulator representing 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol or a pharmaceutically acceptable salt thereof, lactulose, polyethylene glycol-6000 and polyvinylpyrrolidone. What is also described is a drug preparation containing 2- amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol or a pharmaceutically acceptable salt thereof, in the form of a tablet or capsule, placed in pharmaceutically acceptable package, and a method for preparing the drug preparation for oral administration.

EFFECT: invention provides a uniform distribution of the active ingredient in the solid composition, high stability and improved flowability of the solid pharmaceutical composition; the improved flowability of the composition presented in the invention enables using the same on automated equipment.

15 cl, 1 tbl, 4 ex