ANTIBODIES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, WHICH ARE SUITABLE FOR INHIBITION OF ACTIVITY OF METALLOPROTEINS Russian patent published in 2014 - IPC C07F3/06 C07K16/40 C07K16/44 A61K39/395 

Abstract RU 2503682 C2

FIELD: biotechnologies.

SUBSTANCE: invention refers to a compound having general formula (I),

where: m and n are independent integer numbers of 1 to 6; each of X1-X3 and Y1-Y3 is O; each of R1-R3 is independently chosen from a group consisting of hydrogen or alkyl; and R is O-(CH2)x-C(-O)NR'-(CH2)y-NHR'. Besides, x and y are independent integer numbers of 1 to 6; and R' is chosen from the group consisting of hydrogen and alkyl. In addition, an antibody containing an antigen recognition area, use of the compound, pharmaceutical composition, use of the antibody, method for MMP-2 or MMP-9 activity inhibition in a sample and a composition for determining MMP-2 or MMP-9 are proposed.

EFFECT: invention allows obtaining compounds that are able to inhibit MMP-2 or MMP-9 activity.

11 cl, 16 dwg, 4 tbl, 11 ex

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RU 2 503 682 C2

Authors

Sagi Irit

Danon Tamar

Sela Netta

Shantser Abrakham

Arad-Jellin Rina

Kikkeri Ragkhavendra

Dates

2014-01-10Published

2008-02-21Filed