MODE OF DOSING SELECTIVE S1P1 RECEPTOR AGONIST Russian patent published in 2014 - IPC A61K31/426 A61P37/06 A61P17/06 

Abstract RU 2519660 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: claimed are: application of (R)-5-[3-chloro-4-(2,3-dihydroxypropoxy)benz[2]ylidene]-2-([2]-propylimino)-3-ortho-tolylthiazolidin-4-one (compound 1) or its salt for obtaining a medication for prevention and/or treatment of a disease or disorder, associated with the immune system activation, where the medication represents a set of Compound 1 doses; with the dose inducing the heart desensitisation in an initial phase of treatment and being lower than the final dose; with the said initial phase of treatment the dose is introduced with a frequency ensuring support of the heart desensitisation until the next acute reduction of heart rate occurs, after which the dose is titrated with increase to the final dose of Compound 1; a corresponding method of treatment and the set of doses.

EFFECT: invention ensures reduction and minimisation of undesirable side effects of Compound 1 (acute reduction of heart rate, atrioventricular conduction, or fatigue and dizziness) aimed at increase of Compound 1 tolerance and safety, as well as minimises problems, associated with monitoring at the initial phase of treatment or after interruption of treatment in the period of repeated treatment.

22 cl, 1 tbl

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RU 2 519 660 C2

Authors

Patrik Brossar

Jasper Dingemanse

Oliver Najler

Majkl Sherts

Beat Shtajner

Dates

2014-06-20Published

2009-03-12Filed