FIELD: biotechnologies.
SUBSTANCE: method involves advance preparation of dry raw material components containing a matrix and biologically active components; micronising of prepared dry components is performed till 5-150 mcm particle size. Micronised components are supplied to a drying microgranulator in which a fluidised bed is formed and mixing of granulated raw material components is performed with further microgranulation of the obtained mixture and its drying. Microgranulation and drying stages include stable toroidal movement of fluidised bed granules. Microgranulation stage involves addition to the mixture of soluble micro- and ultramicrocomponents by fine atomisation through an atomiser together with a binding agent solution at microgranule formation stage. Addition rate is 0.02-0.04 g/min per gramme of initial dry mixture; after stable toroidal movement of fluidised bed granules is formed, binding agent feed rate is increased up to 0.04-0.08 g/min per gramme of initial dry mixture. With that, granule test sampling is performed from time to time. After granules with size of 0.8-1.0 mm are formed, binding agent feed rate is decreased to 0.01-0.03 g/min per gramme of initial dry mixture and drying is performed at the temperature of 35-55°C.
EFFECT: method ensures uniform distribution of microelements by weight of microgranules, reduction of losses of microelements at their formation and reduction of dust formation at use of premix.
9 cl, 5 dwg, 1 tbl, 3 ex
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Authors
Dates
2014-06-20—Published
2012-11-22—Filed