FIELD: medicine.
SUBSTANCE: invention refers to experimental medicine, namely to simulating inflamed paranasal sinuses accompanying chronic tobacco smoking. That is ensured by placing the rats into an inhalation chamber wherein tobacco smoke containing 98 mg/m of carbon monoxide is supplied. The cigarettes containing tar 11 mg and nicotine 0.8 mg are used. The tobacco smoke is supplied at a rate of 1 cigarette per 8-10 minutes for 1.5 hours daily for 6 months.
EFFECT: method provides adequate simulation of the inflammation processes accompanying chronic exposure to tobacco smoke, which enables studying of the pathogenesis and control of the inflammation, using correction methods, including drug therapy, while reducing the cost of providing the model and reducing the labour intensity of the simulation procedure.
2 dwg, 1 tbl,1 ex
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