SOLID FORMS OF AZOCYCLIC AMIDE Russian patent published in 2014 - IPC C07D417/14 A01N43/80 A01P3/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a crystalline polymorph of 1-[4-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]-1-piperidinyl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone, denoted by Form B, characterised by X-ray powder diffraction at reflected angles of 2θ: 14.902, 18.123, 18.87, 20.204, 20.883, 21.79, 24.186, 26.947. The invention relates to a fungicidal composition containing a crystalline polymorph of 1-[4-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]-1-piperidinyl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone, denoted by Form B, in an effective amount and at least one additional component selected from a group consisting of a surfactant and a liquid carrier. The invention relates to a method of controlling plant diseases caused by fungal plant pathogens, which includes applying a fungicidally effective amount of said polymorph on a plant or part thereof or seeds. The invention also relates to methods of obtaining said crystalline polymorph.

EFFECT: crystalline polymorph of 1-[4-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]-1-piperidinyl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone, having a higher melting point and which is less soluble.

12 cl, 13 tbl, 2 dwg, 25 ex