FIELD: chemistry.
SUBSTANCE: invention refers to a method for producing an acid addition salt of flupirtine by the hydration of 2-amino-6-(4-fluorobenzylamino)-3-nitropyridine, by the interaction of 2,3-diamino-6-(4-fluorobenzylamino)pyridine with chloroformate and a base to produce flupirtine, by the filtration and addition of an acid to an acid filtrate or an acid salt for the deposition of the acid addition salt of flupirtine differing by the fact that it involves the stages: a) hydration of 2-amino-6-(4-fluorobenzylamino)-3-nitropyridine in the presence of palladium on activated carbon in an inert water-mixed solvent, b) interaction of 2,3-diamino-6-(4-fluorobenzyl-amino)pyridine produced at the stage a) with the addition of ethyl chloroformate and the base to produce flupirtine, c) filtration, d) addition of the acid solution or acid salt in water to the filtrate prepared at the stage c), e) deposition of a flupirtine salt with the acid and separation it by filtration.
EFFECT: producing the acid addition salt of flupirtine.
13 cl, 2 dwg, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| PROCESS FOR PREPARING 2-AMINO-3-CARBETHOXYAMINO-6-(N-FLUOROBENZYLAMINO)PYRIDINE MALEATE | 0 |
|
SU1091855A3 |
| 0 |
|
SU560531A3 | |
| IMPROVED METHOD OF PRODUCING 4-BENZIMIDAZOLYL METHYLAMINO)-BENZAMIDE SALTS | 2006 |
|
RU2425827C2 |
| IMPROVED METHOD OF PRODUCING 4-(BENZIMIDAZOLYL METHYLAMINO)-BENZAMIDES AND SALTS THEREOF | 2006 |
|
RU2455292C2 |
| METHOD FOR PREPARING PYRIDO-(1,2-A)PYRIMIDINE DERIVATIVES OR THEIR SALTS | 0 |
|
SU906378A3 |
| 0 |
|
SU416943A3 | |
| VERSIONS OF METHOD OF PRODUCING PYRIDINE-2-ETHERS OR PYRIDINE-2-THIOETHERS OR ACID-ADDITIVE SALTS THEREOF,OR PYRIDINE-N-OXIDES | 0 |
|
SU1417796A3 |
| METHOD OF PREPARING 7-BETA-/D-2-AMINO-2-(LOWEST ALKYLSULFONYLAMINOPHENYL)-ACETYLAMINO/-3-METHOXY (OR CHLORO)-3-CEPHEM-4-CARBOXYLIC ACIDS OR THEIR SALTS | 0 |
|
SU803862A3 |
| METHOD OF PREPARING 7-AZABENZIMIDAZOLES OR THEIR SALTS | 0 |
|
SU795478A3 |
| 0 |
|
SU458129A3 |
