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2 540 080

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(51)

IPC

C07C231/12(2006-01-01)

C07C233/06(2006-01-01)

C07C233/08(2006-01-01)

C07C323/22(2006-01-01)

C07C319/20(2006-01-01)

(21) (22)

Application

2013104851/04, 2013-02-05

(24)

Start date

2013-02-05

(22)

Actual filing date

2013-02-05

(45)

Published

2015-01-27

(72)

Inventor

Dzhemilev Usein MemetovichTuktarov Ajrat RamilevichKhuzina Lilija Linatovna

(73)

Holder

Federal'Noe Gosudarstvennoe Bjudzhetnoe Uchrezhdenie Nauki Institut Neftekhimii I Kataliza Rossijskoj Akademii Nauk

METHOD OF SELECTIVE OBTAINING OF 1'-ALKYL-1'-N-CYCLOHEXYLCARBOXAAMIDYLCYCLOPROPA[2',3':1,9](C-I)[5,6]FULLERENES Russian patent published in 2015 - IPC C07C231/12 C07C233/06 C07C233/08 C07C323/22 C07C319/20

Abstract RU 2540080 C2

FIELD: chemistry.

SUBSTANCE: invention relates to field of organic chemistry, namely to method of obtaining functionally substituted fullerenes, which can be applied as highly active initial substances in synthesis of medications of new generation for treatment of dangerous human diseases. method of selective obtaining of 1'-alkyl-1'-N- cyclohexylcarboxaamidylcyclopropa[2',3':1,9](C₆₀-Ih)[5,6]fullerenes (1) is realised due to interaction of C₆₀-fullerene with α-substituted diazoamides of formula N₂C(R)C(O)NHCy (R=Me, i-Bu, -(CH₂)₂SMe) in o-dichlorobenzene in presence of three-component catalyst {Pd(acac)₂:2PPh₃:4Et₃Al}, taken in molar ratio C₆₀:diazocompound:Pd(acac)₂:PPh₃:Et₃Al=0.01:(0.03-0.07):(0.0015-0.0025):(0.003-0.005):(0.006-0.01) Interaction is performed at temperature 80°C for 0.2-1.0 h.

EFFECT: selective obtaining of 1'-alkyl-1'-N- cyclohexylcarboxaamidylcyclopropa[2',3':1,9](C₆₀-Ih)[5,6]fullerenes .

1 tbl

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RU 2 540 080 C2

Authors

Dzhemilev Usein Memetovich

Tuktarov Ajrat Ramilevich

Khuzina Lilija Linatovna

Dates

2015-01-27—Published

2013-02-05—Filed