METHOD AND MEMBRANE FOR SKIN REGENERATION Russian patent published in 2015 - IPC A61F2/10 A61K38/39 A61P17/02 

FIELD: medicine.

SUBSTANCE: group of inventions refers to medicine, namely to dermatology and surgery, and can be used for skin regeneration, repair and grafting. That is ensured by using an absorbable multilayer structure. That is preceded by preparing (adapting) this structure by exposing to an UV lamp at an emitting power of 10-20 W at 15-45 cm from a collagen sponge surface of the membrane for 2-4 hours. Alternatively, the adaptation procedure is developed by cross-linking with dehydration and thermal treatment in the vacuum medium at a pressure <200 mbar and 100°C for 24 hours or with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) in a water solution containing approximately 0.1-0.6 g of EDC in approximately 0.3-2 g of the collagen sponge matrix. Cross-linking agents, such as hyaluronan, hexethylene diisocyamate, N-hydroxysuccinimide (NHS) or hyoxal are used. The above absorbable multilayer structure comprises a barrier laminate of a purified collagen made of a natural collagen-containing material. The barrier laminate contains a barrier layer comprising a smooth barrier surface and a fibrous surface on the side opposite the above smooth surface. Additionally, the matrix layer comprises the collagen sponge material made of pig skin. The presented multilayer structure is adapted so that the matrix layer is absorbed by the body within approximately 2-5 weeks, while the collagen barrier laminate is absorbed substantially completely within approximately 6-11 weeks.

EFFECT: group of inventions provides the effective skin replacement for the purpose of skin reconstruction, repair and regeneration, eg following surgical interventions.

35 cl, 3 dwg, 5 ex