ANTI-CD38 ANTIBODY AND LENALTDOMID OR BORTEZOMIB FOR TREATING MULTIPLE MYELOMA AND NHL Russian patent published in 2016 - IPC A61K39/395 

Abstract RU 2595839 C2

FIELD: medicine.

SUBSTANCE: invention represents a synergetic combination of (1) antibody specific to CD38 containing HCDR1 section with SYYMN sequence (SEQ ID NO: 14) or GFTFSSYYMN (SEQ ID NO: 1), HCDR2 section with GISGDPSNTYYADSVKG sequence (SEQ ID NO: 2), HCDR3 section with DLPLVYTGFAY sequence (SEQ ID NO: 3), LCDR1 section with SGDNLRHYYVY sequence (SEQ ID NO: 4), LCDR2 section with GDSKRPS sequence (SEQ ID NO: 5) and LCDR3 section with QTYTGGASL sequence (SEQ ID NO: 6), and (2) lenalidomide, pomalidomide or bortezomib, for use in treating multiple myeloma and/or non-Hodgkin lymphoma.

EFFECT: invention is effective in treating said tumour diseases.

17 cl, 20 dwg, 21 tbl, 12 ex

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RU 2 595 839 C2

Authors

Rojker Liza

Bokskhammer Rajner

Endell Yan

Vinderlikh Mark

Samuelsson Kristofer

Dates

2016-08-27Published

2011-09-26Filed