METHOD FOR PRODUCTION OF PHARMACEUTICAL COMPOSITION WITH FEXOFENADINE, PROVIDING ANTI-ALLERGIC AND ANTI-INFLAMMATORY EFFECT Russian patent published in 2017 - IPC A61K31/445 A61K47/00 A61K9/06 A61J3/04 A61P29/00 A61P37/08 

FIELD: pharmacy.

SUBSTANCE: pharmaceutical composition for fexofenadine gel preparation contains the following auxiliary components: thickener - Carbopol, neutralizing agent - sodium hydroxide 5% solution, glycerin and purified water. First, a hydrophilic base is prepared - carbopol is mixed with glycerol at a ratio of 1:20, with vigorous stirring, purified water is added, and the resulting system is stirred until complete homogenization, fexofenadine is then dissolved in 5% sodium hydroxide solution, the resulting fexofenadine alkaline solution is gradually added to the hydrophilic base with vigorous stirring to obtain a gel composition with a pH of 6.5. The gel is stored at a temperature of 15÷25°C for 2 years, if an increased storage life of the gel composition is required, nipagin or benzalkonium chloride is introduced.

EFFECT: fexofenadine gel has a high therapeutic efficacy with minimal side effects, and low cost.

1 tbl, 4 ex