ORAL PHARMACEUTICAL COMPOSITION OF DIURETICS AND ACE INHIBITOR IN MICRONIZED FORM, DRUG AND ITS APPLICATION Russian patent published in 2017 - IPC A61K45/06 A61K31/4045 A61K31/403 A61K31/00 A61K47/00 A61P9/12 A61P9/00 

FIELD: medicine, pharmacy.

SUBSTANCE: invention refers to medicine, namely to pharmacy. The pharmaceutical composition contains active ingredients - ramipril (angiotensin-converting enzyme (ACE) inhibitor) and indapamide (sulfonamide diuretic) or pharmaceutically acceptable salts thereof. The active ingredients are in micronized form with average particle size less than 50 microns. The pharmaceutical composition comprises lactose monohydrate, colloidal silicon dioxide and calcium stearate as auxiliary substances. The composition provides a dissolution nature such that at least 80% of the ramipril is released within 45 minutes and at least 80% of indapamide is released within 45 minutes. A hypotensive-effect drug which contains 0.5 - 2.5 mg of indapamide and 1-20 mg of ramipiril is also described. Application of a combined agent containing indapamide and ramipril as a means with cerebral and organ protection properties is also described.

EFFECT: invention allows expansion of the range of domestic drugs with hypotensive effect, with the required characteristics and a shelf life of 5 years.

4 cl, 12 dwg, 16 tbl