FIELD: technological processes.
SUBSTANCE: invention relates to a process for the preparation of mepreghenol di-acetate comprising the step of reducing the megestrol acetate with sodium borohydride in an alcoholic solution to obtain a steroidal alcohol (mepreghenol 17-acetate) and the reaction of its acetylation with acetic anhydride, in which the reduction step is carried out in aqueous isopropyl alcohol with a water content of 10 to 20 % in the presence of hydrochloric acid and at a temperature maintained in the range of 11±2 °C, the acetylation is carried out in acetone in the presence of a tertiary amine or a combination of tertiary amines as a catalyst, followed by precipitation of the desired product with aqueous ammonia.
EFFECT: simple and safe method for producing high-yield diacetate of mepreghenol is developed, which provides the possibility of scaling the process.
5 cl, 1 tbl, 3 ex
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