FIELD: pharmaceuticals.
SUBSTANCE: proposed use of 3β,5α,6β-trihydroxyl steroid compound of formula A or a pharmaceutically acceptable salt thereof for the preparation of a pharmaceutical composition for prevention or treatment of altitude sickness caused by hypobaric hypoxia. .
EFFECT: as a result, 5α-androstane-3β,5,6β-triol and its salts effectively reduce the vasogenic edema of the brain tissue in the cynomolgus macaques (Macaca fascicularis), caused by hypobaric hypoxia, reduce the increased water content in the brain and provide protection against neuronal vacuolar degeneration caused by hypobaric hypoxia – so it or its salts can improve neurological dysfunctions, caused by hypobaric hypoxia, and are suitable for the prevention or treatment of altitude sickness.
7 cl, 3 dwg, 2 tbl
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Authors
Dates
2018-11-13—Published
2015-04-14—Filed