ANTISENSE NUCLEIC ACIDS Russian patent published in 2019 - IPC C07H21/00 A61P19/00 

FIELD: biotechnology.

SUBSTANCE: described antisense oligomer, that causes the skipping of the 55th exon in the human dystrophin gene, consisting of a nucleotide sequence complementary to any of the nucleotide sequences consisting of 10–31st, 10–32nd, 11–31st, 11–32nd, 13–34th, 13–35th, 13–36th, 14–35th, 14–36th, 15-35th, 15-36th, 16–34th, 16–35th or 16–36th nucleotides, counting from the 5'-end of the 55th exon of the human dystrophin gene.

EFFECT: pharmaceutical composition comprising the said oligomer is presented.

10 cl, 31 dwg, 15 tbl, 39 ex