FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one. Method involves condensation of 5-chloro-2-methyl-aminobenzophenone with chloroacetyl chloride at temperature of 72–78 °C in tetrachloromethane carbon medium, reacting obtained 2-benzoyl-2',4-dichloro-N-methylacetanilide with hexamethylenetetramine in isopropyl alcohol medium at temperature of 78–82 °C.
EFFECT: method enables to reduce duration of the process, minimize the number of steps, simplify the used process equipment, eliminate hazardous reagents and can be used on an industrial scale.
1 cl, 2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| 0 |
|
SU466660A3 | |
| METHOD OF SYNTHESIS OF DRUG NITRAZEPAM - 1,3-DIHYDRO-5-PHENYL-7-NITRO-2H-1,4-BENZODIAZEPINE-2-ONE | 1996 |
|
RU2136285C1 |
| 0 |
|
SU550980A3 | |
| 0 |
|
SU497774A3 | |
| 0 |
|
SU324746A1 | |
| METHOD OF PREPARING BENZODIAZEPINE DERIVATIVES OR SALTS THEREOF | 0 |
|
SU584772A3 |
| 0 |
|
SU436495A3 | |
| 0 |
|
SU517258A3 | |
| METHOD OF SYNTHESIS OF 1,3-DIHYDRO-7-NITRO-5-PHENYL-2H-1,4- -BENZODIAZEPINE-2-ONE (NITRAZEPAM) (VARIANTS) | 1998 |
|
RU2150467C1 |
| 0 |
|
SU428603A3 |
