FIELD: biotechnology.
SUBSTANCE: present invention refers to biotechnology. There are presented antibodies and their antigen-binding fragments against IL-1-beta. Besides, coding nucleic acid, a vector, a host cell and methods for producing the antibody and its antigen-binding fragment are described. Also provided are a pharmaceutical composition and a method of treating a disease associated with IL-1 beta; a kit and a method of detecting presence of IL-1 beta in a biological sample.
EFFECT: present invention can be used in treating and diagnosing various inflammatory diseases.
45 cl, 6 dwg, 7 tbl, 10 ex
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