PHARMACEUTICAL COMBINATIONS FOR TREATING A MALIGNANT TUMOR Russian patent published in 2020 - IPC A61K31/40 A61K31/4025 A61K31/496 A61K31/69 A61P35/00 A61K35/02 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: first invention represents a method of treating a malignant blood tumor, comprising administering to an individual a CDK inhibitor corresponding to the formula:

,

or a pharmaceutically acceptable salt thereof, where: R₁ denotes phenyl substituted with one or two substitutes independently selected from halogen and halomethyl; each of R₂ and R₃ is independently selected from hydroxy and OR₈, where R₈ is C₁-C₁₀-alkyl; R₄ denotes CH₂OH; and R₉ is hydrogen or methyl; and venetoclax or its pharmaceutically acceptable salt. Second invention is a method of treating a malignant tumor, comprising administering to a subject said CDK inhibitor and a proteasome inhibitor selected from bortezomib, marizomib, ixazomib and their pharmaceutically acceptable salts. Third inventor represents a pharmaceutical composition comprising said CDK inhibitor and venetoclax or proteasome inhibitor, selected from bortezomib, marizomib, ixazomib or their pharmaceutically acceptable salts.

EFFECT: disclosed are pharmaceutical combinations for treating malignant tumor.

41 cl, 33 dwg, 4 tbl, 16 ex