FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology and is a variant of nucleic acids with CpG reduced content encoding a FVIII protein and methods for the use thereof.
EFFECT: nucleic acid with CpG reduced content variants encoding FVIII are more efficiently expressed by cells, secreted at higher levels by cells than by a wild protein factor VIII, exhibit increased expression and/or activity compared to the protein factor VIII of the wild type or are more efficiently packaged in viral vectors.
105 cl, 15 dwg, 6 tbl, 10 ex
| Title | Year | Author | Number |
|---|---|---|---|
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|
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RU2789085C2 |
