FIELD: pharmaceutics.
SUBSTANCE: group of inventions relates to the field of pharmaceutics, namely to a liquid composition of an antibody against TNF-α and a method for its preparation. The liquid composition contains an antibody against TNF-α, a stabilizer, which is polyol, amino acid other than arginine, or a combination thereof, a surfactant, methionine and arginine in certain concentrations, wherein the liquid composition does not contain an additional buffer. The method for preparation of a liquid composition includes mixing an antibody against TNF-α, a stabilizer, a surfactant, methionine and arginine.
EFFECT: group of inventions provides improved stability of an antibody against TNF-α in a liquid composition containing a stabilizer, a surfactant and arginine, without an additional buffer, due to the addition of an antioxidant – methionine.
13 cl, 18 tbl, 2 dwg, 14 ex
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