NEW HETEROCYCLIC AMINE DERIVATIVE AND A PHARMACEUTICAL COMPOSITION CONTAINING IT Russian patent published in 2021 - IPC C07D417/12 C07D417/14 C07D403/14 C07D487/04 A61K31/4427 A61K31/4523 A61K31/496 A61K31/506 A61P35/00 A61P37/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound represented by chemical formula 1 or a pharmaceutically acceptable salt thereof, wherein B is a thiazole, pyrazole, pyridine or pyrimidine ring, R₁ is hydrogen, halogen, C_1-4 alkyl or C_1-4 haloalkyl, each of X₁ and X₂ is independently N or CR', where R' is hydrogen or halogen, L is C_1-4 alkylene or -O-, R₂ is cyano, C_1-4 alkyl, phenyl, pyridinyl, morpholino, piperazinyl or piperidinyl, wherein each of piperazinyl and piperidinyl is independently unsubstituted or substituted C_1-4 alkyl, C_1-4 alkyl, substituted cyano, C_1-4 alkyl, substituted amino, C_1-4 alkyl substituted with C_1-4 alkoxy, or -CO- (C_1-4 alkyl), Y is a bond, -O-, -NH- or -N(C_1-4 alkyl)-, A is , , , , or , where R₃ is C_1-4 haloalkyl, C_2-4 alkenyl, C_2-4 haloalkenyl, or C_2-4 alkynyl. The invention also relates to a pharmaceutical composition based on a compound of chemical formula 1.

EFFECT: new compounds and a pharmaceutical composition based on them have been obtained, which can be used in medicine for the prevention or treatment of autoimmune diseases or cancer.

[Chemical formula 1]

15 cl, 1 tbl, 54 ex