FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology, specifically, to the production of therapeutically active peptide conjugates, and can be used in medicine for preventing or treating a disease selected from obesity, diabetes, and non-alcoholic fatty liver disease. Invention ensures the production of a composition comprising a site-specific conjugate with a polypeptide and a non-peptide polymer, exhibiting excellent effect of preventing or treating obesity, diabetes, or non-alcoholic fatty liver disease by increasing the half-life in blood while at the same time maintaining the activity of the polypeptide in vivo.
EFFECT: pharmaceutical composition is safe in terms of side effects, such as vomiting or nausea, and has the effects of reducing food intake, increasing insulin secretion, preventing bowel evacuation, promoting lipolysis, and lowering the triglyceride levels.
19 cl, 14 dwg, 9 tbl, 10 ex
| Title | Year | Author | Number |
|---|---|---|---|
| PHARMACEUTICAL COMPOSITION FOR NON-ALCOHOLIC FATTY LIVER DISEASE PREVENTION OR TREATMENT | 2013 |
|
RU2635966C2 |
| COMPOSITION COMPRISING A GLP-1 RECEPTOR AGONIST AND A GLUCAGON RECEPTOR AGONIST, AND USE THEREOF | 2016 |
|
RU2719144C2 |
| COMPOSITION FOR HYPERLIPIDEMIA TREATMENT CONTAINING OXYNTOMODULIN DERIVATIVE | 2013 |
|
RU2642267C2 |
| PHARMACEUTICAL COMPOSITION FOR TREATING OBESITY-RELATED DISEASES CONTAINING INSULINOTROPIC PEPTIDE CONJUGATE | 2008 |
|
RU2446816C2 |
| COMPOSITION FOR TREATING HYPERLIPIDEMIA CONTAINING AN OXYNTOMODULIN DERIVATIVE | 2013 |
|
RU2768853C1 |
| COMPOSITION FOR TREATING DIABETES, CONTAINING LONG-ACTING INSULIN CONJUGATE AND LONG-ACTING INSULINOTROPIC PEPTIDE CONJUGATE | 2012 |
|
RU2606840C2 |
| NOVEL PROTEIN CONJUGATE AND USE THEREOF FOR PREVENTING OR TREATING NON-ALCOHOLIC STEATOHEPATITIS, OBESITY AND DIABETES | 2021 |
|
RU2822001C1 |
| CONJUGATE CONTAINING OXINTOMODULIN AND IMMUNOGLOBULIN FRAGMENT, AND ITS APPLICATION | 2012 |
|
RU2733544C2 |
| CONJUGATE, CONTAINING OXYNTOMODULIN AND FRAGMENT OF IMMUNOGLOBULIN, AND USE THEREOF | 2012 |
|
RU2607365C2 |
| INSULINOTROPIC COMPLEX IN WHICH IMMUNOGLOBULIN FRAGMENT IS USED | 2008 |
|
RU2436589C2 |
