METHOD FOR OBTAINING A DEXTRANASE PREPARATION AND ITS USE Russian patent published in 2023 - IPC C12N9/46 A61K8/66 A61K9/10 

FIELD: biotechnology.

SUBSTANCE: invention relates to biotechnology, in particular to a method for obtaining a dextranase preparation Aspergillus insuetus VKMP F - 342. The method includes: obtaining a working culture on a slant agar; preparation of deep sowing culture in flasks; preparation of a deep seed culture in a fermenter; carrying out the process of biosynthesis in fermenters; separation on the flow separator; concentration of the native solution in an ultrafiltration unit; mixing with mannitol, sterilizing filtration, freezing; freeze drying, while mannitol is added at the rate of 1 g per 8000-12000 units activity. The invention also relates to a dextranase preparation Aspergillus insuetus VKMP F - 342, which has an increased activity and applications of this drug for the treatment and prevention of dental caries and gingivitis. In addition, the invention is directed to oral care products using the preparation.

EFFECT: invention makes it possible to obtain a dextranase preparation with increased activity. 7 cl, 8 tbl