COMPOSITIONS AND THEIR USE Russian patent published in 2023 - IPC A23L33/15 A23L33/16 A23L33/115 

FIELD: artificial nutritional composition.

SUBSTANCE: artificial nutritional composition contains folic acid in an amount of more than 110 μg/100 g dry weight of the composition proposed for prevention, reduction of the risk or mitigation a suboptimal de novo myelination trajectory in a human infant or child. However, the de novo myelination trajectory is suboptimal when the distance between any equivalent and/or identical infant trajectory measurement points and the trajectory achieved in exclusively breastfed infants during their first (3) months of life is greater than 50%. The artificial nutritional composition includes folic acid and vitamin B12 as well as choline and/or iron and/or fatty acid compounds such as docosahexaenoic acid (DHA) and/or arachidonic acid (ARA) and/or sphingomyelin and/or monoacylglycerol, and/or diacylglycerol and/or triacylglycerol. Moreover, sphingomyelin in the specified composition - NLT 420 mg/kg, folic acid - NLT 110 μg/100 g of dry weight of the composition, vitamin B12 - NLT 5 μg/100 g, iron - NLT 6 mg/100 g, choline - NLT 140 mg/kg, DHA - NLT 89 mg/100 g, ARA - NLT 89 mg/100 g.

EFFECT: prevention of suboptimal brain structure and brain connectivity by optimizing de novo myelination in the human infant or child brain.

10 cl, 65 dwg, 15 tbl, 8 ex