FIELD: medicine; pharmacology; pharmaceutical industry.
SUBSTANCE: group of inventions includes a method for producing (1R,2S,5S)-N-[(1S)-1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl]-3-[(2S)-3,3-dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide (compound of formula (I)) and its use for batch chemical industrial production, semi-continuous industrial production or continuous industrial production. The method for obtaining the compound of formula (I) consists in the dehydration of the compound of formula (II) using 2,4,6-trichloro-1,3,5-triazine in a solvent medium.
EFFECT: improved method of obtaining, leading to an increase in the yield and chemical purity of the compound of formula (I).
14 cl, 1 tbl, 2 ex
| Title |
Year |
Author |
Number |
| METHOD FOR PRODUCING (1R,2S,5S)-N-[(1S)-1-CYANO-2-[(3S)-2-OXOPYRRROLIDIN-3-YL]ETHYL]-3-[(2S)-3,3- DIMETHYL-2-[(2,2,2-TRIFLUORACETYL)AMINO]BUTANOYL]-6,6-DIMETHYL-3-AZABICYCLO[3.1.0]HEXAN-2-CARBOXAMIDE |
2022 |
- Belyj Petr Aleksandrovich
- Lopatukhin Eduard Yurevich
- Korolev Vladimir Lvovich
- Zaslavskaya Kira Yakovlevna
- Belov Evgenij Yurevich
|
RU2794750C1 |
| METHOD FOR PRODUCING (1R,2S,5S)-N-[(1S)-1-CYANO-2-[(3S)-2-OXOPYRRROLIDIN-3-YL]ETHYL]-3-[(2S)-3,3- DIMETHYL-2-[(2,2,2-TRIFLUORACETYL)AMINO]BUTANOYL]-6,6-DIMETHYL-3-AZABICYCLO[3.1.0]HEXAN-2-CARBOXAMIDE |
2022 |
- Belyj Petr Aleksandrovich
- Lopatukhin Eduard Yurevich
- Korolev Vladimir Lvovich
- Zaslavskaya Kira Yakovlevna
- Belov Evgenij Yurevich
|
RU2794754C1 |
| METHOD FOR PRODUCING (1R,2S,5S)-N-[(1S)-1-CYANO-2-[(3S)-2-OXOPYRRROLIDIN-3-YL]ETHYL]-3-[(2S)-3,3- DIMETHYL-2-[(2,2,2-TRIFLUORACETYL)AMINO]BUTANOYL]-6,6-DIMETHYL-3-AZABICYCLO[3.1.0]HEXAN-2-CARBOXAMIDE |
2022 |
- Belyj Petr Aleksandrovich
- Lopatukhin Eduard Yurevich
- Korolev Vladimir Lvovich
- Zaslavskaya Kira Yakovlevna
- Belov Evgenij Yurevich
|
RU2794746C1 |
| METHOD FOR PRODUCING (1R,2S,5S)-N-[(1S)-1-CYANO-2-[(3S)-2-OXOPYRRROLIDIN-3-YL]ETHYL]-3-[(2S)-3,3- DIMETHYL-2-[(2,2,2-TRIFLUORACETYL)AMINO]BUTANOYL]-6,6-DIMETHYL-3-AZABICYCLO[3.1.0]HEXAN-2-CARBOXAMIDE |
2022 |
- Belyj Petr Aleksandrovich
- Lopatukhin Eduard Yurevich
- Korolev Vladimir Lvovich
- Zaslavskaya Kira Yakovlevna
- Belov Evgenij Yurevich
|
RU2794755C1 |
| NOVEL FORMS OF (1R,2S,5S)-N-[(1S)-1-CYANO-2-[(3S)-2-OXOPYRROLIDIN-3-YL]ETHYL]-3-[(2S)-3,3-DIMETHYL-2-[(2,2,2-TRIFLUOROACETYL)AMINO]BUTANOYL]-6,6-DIMETHYL-3-AZABICYCLO[3.1.0]HEXANE-2-CARBOXAMIDE |
2023 |
- Belyi Petr Aleksandrovich
- Lopatukhin Eduard Iurevich
- Korolev Vladimir Lvovich
- Zaslavskaia Kira Iakovlevna
- Korliukov Aleksandr Aleksandrovich
- Buikin Petr Alekseevich
|
RU2827154C1 |
| NOVEL FORMS OF (1R,2S,5S)-N-[(1S)-1-CYANO-2-[(3S)-2-OXOPYRROLIDIN-3-YL]ETHYL]-3-[(2S)-3,3-DIMETHYL-2-[(2,2,2-TRIFLUOROACETYL)AMINO]BUTANOYL]-6,6-DIMETHYL-3-AZABICYCLO[3.1.0]HEXANE-2-CARBOXAMIDE |
2023 |
- Belyi Petr Aleksandrovich
- Lopatukhin Eduard Iurevich
- Korolev Vladimir Lvovich
- Zaslavskaia Kira Iakovlevna
- Korliukov Aleksandr Aleksandrovich
- Buikin Petr Alekseevich
|
RU2827357C1 |
| NOVEL FORMS OF (1R,2S,5S)-N-[(1S)-1-CYANO-2-[(3S)-2-OXOPYRROLIDIN-3-YL]ETHYL]-3-[(2S)-3,3-DIMETHYL-2-[(2,2,2-TRIFLUOROACETYL)AMINO]BUTANOYL]-6,6-DIMETHYL-3-AZABICYCLO[3.1.0]HEXANE-2-CARBOXAMIDE |
2023 |
- Belyi Petr Aleksandrovich
- Lopatukhin Eduard Iurevich
- Korolev Vladimir Lvovich
- Zaslavskaia Kira Iakovlevna
- Korliukov Aleksandr Aleksandrovich
- Buikin Petr Alekseevich
|
RU2827358C1 |
| NOVEL FORMS OF (1R,2S,5S)-N-[(1S)-1-CYANO-2-[(3S)-2-OXOPYRROLIDIN-3-YL]ETHYL]-3-[(2S)-3,3-DIMETHYL-2-[(2,2,2-TRIFLUOROACETYL)AMINO]BUTANOYL]-6,6-DIMETHYL-3-AZABICYCLO[3.1.0]HEXANE-2-CARBOXAMIDE |
2023 |
- Belyi Petr Aleksandrovich
- Lopatukhin Eduard Iurevich
- Korolev Vladimir Lvovich
- Zaslavskaia Kira Iakovlevna
- Korliukov Aleksandr Aleksandrovich
- Buikin Petr Alekseevich
|
RU2827157C1 |
| NOVEL FORMS OF (1R,2S,5S)-N-[(1S)-1-CYANO-2-[(3S)-2-OXOPYRROLIDIN-3-YL]ETHYL]-3-[(2S)-3,3-DIMETHYL-2-[(2,2,2-TRIFLUOROACETYL)AMINO]BUTANOYL]-6,6-DIMETHYL-3-AZABICYCLO[3.1.0]HEXANE-2-CARBOXAMIDE |
2023 |
- Belyi Petr Aleksandrovich
- Lopatukhin Eduard Iurevich
- Korolev Vladimir Lvovich
- Zaslavskaia Kira Iakovlevna
- Korliukov Aleksandr Aleksandrovich
- Buikin Petr Alekseevich
|
RU2827158C1 |
| NEW AZABICYCLOHEXANE DERIVATIVES |
2023 |
- Belyi Petr Aleksandrovich
- Lopatukhin Eduard Iurevich
- Korolev Vladimir Lvovich
- Zaslavskaia Kira Iakovlevna
- Korliukov Aleksandr Aleksandrovich
- Buikin Petr Alekseevich
|
RU2811800C1 |
